Accepted for/Published in: JMIR Data
Date Submitted: Jan 29, 2022
Open Peer Review Period: Jan 28, 2022 - Mar 25, 2022
Date Accepted: Jul 18, 2022
(closed for review but you can still tweet)
CASCADE- a Database of Randomized Trials on the HIV Care Cascade: Descriptive Study
ABSTRACT
Background:
The UNAIDS targets for 2030 regarding people living with HIV, adhering to antiretroviral therapy, and achieving viral suppression are ambitious and are on track to being met by several countries. However, within and across countries, several vulnerable populations may not meet these targets.
Objective:
The CASCADE database is designed to inform, support, and improve HIV care cascade research, systematic reviews, and evidence maps.
Methods:
PubMed, Excerpta Medica data BASE, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, Web of Science and the Cochrane Library were searched to obtain randomized trials designed to report on at least one care cascade outcome. Data was screened and extracted using DistillerSR software and catalogued based on the year, income level, setting, delivery of intervention, population receiving the intervention, intervention type, and level of pragmatism of the intervention.
Results:
298 HIV clinical trials are included in the CASCADE database, of which 53.6% were conducted in high income countries, and 38.7% targeted vulnerable populations. Adherence is the most investigated HIV care cascade outcome (71.2%). CASCADE has a user-friendly interface, with simple and advanced search features. The CASCADE database has inspired two methodological papers and 3714 website visits from over 10 countries.
Conclusions:
CASCADE is the first database dedicated to trials focused on the HIV care cascade and can be used for systematic reviews, evidence maps, and methodological research. It is freely accessible and the data
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