Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: JMIR Medical Informatics

Date Submitted: Jun 20, 2021
Open Peer Review Period: Jun 18, 2021 - Aug 13, 2021
Date Accepted: Nov 14, 2021
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Real-world Health Data and Precision for the Diagnosis of Acute Kidney Injury, Acute-on-Chronic Kidney Disease, and Chronic Kidney Disease: Observational Study

Triep K, Leichtle AB, Meister M, Fiedler GM, Endrich O

Real-world Health Data and Precision for the Diagnosis of Acute Kidney Injury, Acute-on-Chronic Kidney Disease, and Chronic Kidney Disease: Observational Study

JMIR Med Inform 2022;10(1):e31356

DOI: 10.2196/31356

PMID: 35076410

PMCID: 8826149

Real world health data and precision for diagnosis of Acute Kidney Injury, acute-on-chronic and Chronic Kidney Disease: observational study

  • Karen Triep; 
  • Alexander Benedikt Leichtle; 
  • Martin Meister; 
  • Georg Martin Fiedler; 
  • Olga Endrich

ABSTRACT

Background:

The criteria for the diagnosis of kidney disease outlined in “The Kidney Disease: Improving Global Outcomes (KDIGO)” are based on a patient’s current, historical and baseline data. The diagnosis of acute (AKI), chronic (CKD) and acute-on-chronic kidney disease requires past measurements of creatinine and back-calculation and the interpretation of several laboratory values over a certain period. Diagnosis may be hindered by unclear definition of the individual creatinine baseline and rough ranges of norm values set without adjustment for age, ethnicity, comorbidities and treatment. Classification of the correct diagnosis and the sufficient staging improves coding, data quality, reimbursement, the choice of therapeutic approach and the patient’s outcome.

Objective:

With the help of a complex rule-engine a data-driven approach to assign the diagnoses acute, chronic and acute-on-chronic kidney disease is applied.

Methods:

Real-time and retrospective data from the hospital’s Clinical Data Warehouse of in- and outpatient cases treated between 2014 – 2019 is used. Delta serum creatinine, baseline values and admission and discharge data are analyzed. A KDIGO based standard query language (SQL) algorithm applies specific diagnosis (ICD) codes to inpatient stays. To measure the effect on diagnosis, Text Mining on discharge documentation is conducted.

Results:

We show that this approach yields an increased number of diagnoses as well as higher precision in documentation and coding (unspecific diagnosis ICD N19* coded in % of N19 generated 17.8 in 2016, 3.3 in 2019).

Conclusions:

Our data-driven method supports the process and reliability of diagnosis and staging and improves the quality of documentation and data. Measuring patients’ outcome will be the next step of the project.


 Citation

Please cite as:

Triep K, Leichtle AB, Meister M, Fiedler GM, Endrich O

Real-world Health Data and Precision for the Diagnosis of Acute Kidney Injury, Acute-on-Chronic Kidney Disease, and Chronic Kidney Disease: Observational Study

JMIR Med Inform 2022;10(1):e31356

DOI: 10.2196/31356

PMID: 35076410

PMCID: 8826149

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.