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Accepted for/Published in: JMIR mHealth and uHealth

Date Submitted: Apr 23, 2021
Open Peer Review Period: Apr 22, 2021 - Apr 29, 2021
Date Accepted: May 31, 2021
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Predicting Depressive Symptom Severity Through Individuals’ Nearby Bluetooth Device Count Data Collected by Mobile Phones: Preliminary Longitudinal Study

Zhang Y, Folarin AA, Sun S, Cummins N, Ranjan Y, Rashid Z, Conde P, Stewart C, Laiou P, Matcham F, Oetzmann C, Lamers F, Siddi S, Simblett S, Rintala A, Mohr DC, Myin-Germeys I, Wykes T, Haro JM, Pennix BW, Narayan VA, Annas P, Hotopf M, Dobson RJ, RADAR-CNS Consortium

Predicting Depressive Symptom Severity Through Individuals’ Nearby Bluetooth Device Count Data Collected by Mobile Phones: Preliminary Longitudinal Study

JMIR Mhealth Uhealth 2021;9(7):e29840

DOI: 10.2196/29840

PMID: 34328441

PMCID: 8367113

Predicting Depressive Symptom Severity through Individuals’ Nearby Bluetooth Devices Count Data Collected by Mobile Phones: A Preliminary Longitudinal Study

  • Yuezhou Zhang; 
  • Amos A Folarin; 
  • Shaoxiong Sun; 
  • Nicholas Cummins; 
  • Yatharth Ranjan; 
  • Zulqarnain Rashid; 
  • Pauline Conde; 
  • Callum Stewart; 
  • Petroula Laiou; 
  • Faith Matcham; 
  • Carolin Oetzmann; 
  • Femke Lamers; 
  • Sara Siddi; 
  • Sara Simblett; 
  • Aki Rintala; 
  • David C Mohr; 
  • Inez Myin-Germeys; 
  • Til Wykes; 
  • Josep Maria Haro; 
  • Brenda WJH Pennix; 
  • Vaibhav A Narayan; 
  • Peter Annas; 
  • Matthew Hotopf; 
  • Richard JB Dobson; 
  • RADAR-CNS Consortium

ABSTRACT

Background:

Research in mental health has found associations between depression and individuals’ behaviors and status, such as social connections and interactions, working status, mobility, and social isolation and loneliness. These behaviors and status can be approximated by the nearby Bluetooth devices count (NBDC) detected by the Bluetooth sensors in mobile phones.

Objective:

This paper aims to explore the NBDC data’s value in predicting depressive symptom severity as measured via the 8-item Patient Health Questionnaire (PHQ-8).

Methods:

The data used in this paper included 2,886 bi-weekly PHQ-8 records collected from 316 participants recruited from three study sites in the Netherlands, Spain, and the UK as part of the EU RADAR-CNS study. From the NBDC data two weeks prior to each PHQ-8 score, we extracted 49 Bluetooth features, including statistical features and nonlinear features for measuring periodicity and regularity of individuals’ life rhythms. Linear mixed-effect models were used to explore associations between Bluetooth features and the PHQ-8 score. We then applied hierarchical Bayesian linear regression models to predict the PHQ-8 score from the extracted Bluetooth features.

Results:

A number of significant associations were found between Bluetooth features and depressive symptom severity. Generally speaking, along with the depressive symptoms worsening, one or more of the following changes were found in the preceding two weeks’ NBDC data: (1) the amount decreased, (2) the variance decreased, (3) the periodicity (especially the circadian rhythm) decreased, and (4) the NBDC sequence became more irregular. Compared with commonly used machine learning models, the proposed hierarchical Bayesian linear regression model achieved the best prediction metrics, R^2= 0.526, and root mean squared error (RMSE) of 3.891. Bluetooth features can explain an extra 18.8% of the variance in the PHQ-8 score relative to the baseline model without Bluetooth features (R^2=0.338, RMSE = 4.547).

Conclusions:

Our statistical results indicate that the NBDC data has the potential to reflect changes in individuals’ behaviors and status concurrent with the changes in the depressive state. The prediction results demonstrate the NBDC data has a significant value in predicting depressive symptom severity. These findings may have utility for mental health monitoring practice in real-world settings.


 Citation

Please cite as:

Zhang Y, Folarin AA, Sun S, Cummins N, Ranjan Y, Rashid Z, Conde P, Stewart C, Laiou P, Matcham F, Oetzmann C, Lamers F, Siddi S, Simblett S, Rintala A, Mohr DC, Myin-Germeys I, Wykes T, Haro JM, Pennix BW, Narayan VA, Annas P, Hotopf M, Dobson RJ, RADAR-CNS Consortium

Predicting Depressive Symptom Severity Through Individuals’ Nearby Bluetooth Device Count Data Collected by Mobile Phones: Preliminary Longitudinal Study

JMIR Mhealth Uhealth 2021;9(7):e29840

DOI: 10.2196/29840

PMID: 34328441

PMCID: 8367113

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