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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Nov 9, 2020
Date Accepted: Jan 16, 2021
Date Submitted to PubMed: Jan 19, 2021

The final, peer-reviewed published version of this preprint can be found here:

SARS-CoV-2 Wave Two Surveillance in East Asia and the Pacific: Longitudinal Trend Analysis

Post LA, Lin JS, Moss CB, Murphy RL, Ison MG, Achenbach CJ, Resnick D, Singh LN, White J, Welch SB, Oehmke JF

SARS-CoV-2 Wave Two Surveillance in East Asia and the Pacific: Longitudinal Trend Analysis

J Med Internet Res 2021;23(2):e25454

DOI: 10.2196/25454

PMID: 33464207

PMCID: 7857528

East Asian and the Pacific Surveillance of SARS-CoV-2 Wave Two: Longitudinal Trend Analysis

  • Lori Ann Post; 
  • Jasmine S Lin; 
  • Charles B Moss; 
  • Robert Leo Murphy; 
  • Micahel G Ison; 
  • Chad J Achenbach; 
  • Danielle Resnick; 
  • Lauren Nadya Singh; 
  • Janine White; 
  • Sarah B Welch; 
  • James Francis Oehmke

ABSTRACT

Background:

The COVID-19 pandemic has had a profound global impact on governments, healthcare systems, economies, and populations around the world. Within the East Asia and Pacific region, some countries have mitigated the spread of the novel coronavirus effectively and largely avoided severe negative consequences, while others still struggle with containment. As the second wave reaches East Asia and the Pacific, it becomes more obvious that additional SARS-CoV-2 surveillance is needed to track recent shifts in the pandemic, rates of increase, and persistence.

Objective:

The goal of this study is to provide advanced surveillance metrics for COVID-19 transmission that account for speed, acceleration, jerk, persistence, and weekly shifts in the pandemic, to better understand country risk for explosive growth and those who are managing the pandemic successfully. Existing surveillance coupled with our dynamic metrics of transmission will inform health policy to control the COVID-19 pandemic until an effective vaccine is developed. We provide novel indicators to measure the transmission of disease.

Methods:

Using a longitudinal trend analysis study design, we extracted 330 days of COVID data from public health registries. We use an empirical difference equation to measure the daily number of cases in East Asia and the Pacific as a function of the prior number of cases, the level of testing, and weekly shift variables based on a dynamic panel model that was estimated using the generalized method of moments (GMM) approach by implementing the Arellano-Bond estimator in R.

Results:

Based on standard surveillance metrics, Indonesia, Philippines, and Myanmar are concerning because they have the largest new caseloads at 4,301, 2,588, and 1,387 respectively. However, when looking at the acceleration of new COVID-19 infections, we find that French Polynesia, Malaysia, and Philippines have the rates at 3.17, .22, and .06 per 100,000. These three countries also rank highest in jerk at 15.45, .10 and .04 respectively.

Conclusions:

Two of the most populous countries in East Asia and the Pacific, Indonesia and the Philippines, have alarming surveillance metrics. These two countries rank highest in new infections in the region. The highest rates of speed, acceleration and positive upwards jerk belong to French Polynesia, Malaysia and the Philippines. Positive rates of speed, acceleration and upwards jerk are more likely to result in explosive growth. While all countries in East Asia and Pacific need to be cautious in regards to opening their countries because outbreaks are likely to occur in the second wave of COVID-19, the country of greatest concern remains the Philippines. Based on standard and enhanced surveillance, the Philippines has not gained control of the COVID-19 epidemic, which is particularly troubling because the country ranks 4th in population in the region. Without extreme and rigid social distancing, quarantines, hygiene, and masking to reverse trends, the Philippines will remain on the global top 5 list of worst COVID-19 outbreaks resulting in high morbidity and mortality. The second wave will only exacerbate existing conditions and increase COVID-19 transmissions.


 Citation

Please cite as:

Post LA, Lin JS, Moss CB, Murphy RL, Ison MG, Achenbach CJ, Resnick D, Singh LN, White J, Welch SB, Oehmke JF

SARS-CoV-2 Wave Two Surveillance in East Asia and the Pacific: Longitudinal Trend Analysis

J Med Internet Res 2021;23(2):e25454

DOI: 10.2196/25454

PMID: 33464207

PMCID: 7857528

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