Accepted for/Published in: Journal of Medical Internet Research
Date Submitted: Apr 11, 2020
Date Accepted: Aug 8, 2020
Measurement Properties of Existing Patient Reported Outcome Measures on Medication Adherence: A systematic review
ABSTRACT
Background:
Background:
Medication adherence is essential in improving health outcomes of patients. Various patient reported outcome measures (PROMs) have been developed to measure medication adherence in patients. However, no study summarises these psychometric properties to guide the selection of suitable PROMs.
Objective:
This study aims to provide an overview of medication adherence PROMs, as well as evaluate their methodological quality and overall level of evidence.
Methods:
This study was guided by the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. Relevant articles were retrieved from Embase®, PubMed®, Cochrane Library, Web of Science, and CINAHL. The PROMs were then evaluated based on the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines.
Results:
121 unique medication adherence PROMs from 213 studies were identified. In terms of psychometrics, “hypotheses testing for construct validity” and “internal consistency” were evaluated most frequently (85.0% and 65.0% of the studies respectively). PROMs with at least “moderate” level of evidence for ≥ 5 measurement properties include the Adherence Starts with Knowledge 20 (ASK-20), Compliance Questionnaire-Rheumatology (CQR), General medication adherence scale (GMAS), Hill-Bone Scale, Immunosuppressant therapy barrier scale (ITBS), Medication Adherence Reasons Scale (MARS), 5-Item MARS (MARS-5), 9-Item MARS (MARS-9), 4-item Morisky Medication Adherence Scale (MMAS-4), 8-item MMAS (MMAS-8), Self-efficacy for Appropriate Medication Adherence Scale (SEAMS), Satisfaction with iron chelation therapy (SICT), test of the adherence to inhaler (TAI), and questionnaire by Voils. Of which, only the GMAS has “sufficient (+)” ratings for at least 4 measurement properties.
Conclusions:
This study identified 121 PROMs for medical adherence, and provided synthesized evidence for the measurement properties for these PROMs. The findings from this study may assist clinicians and researchers in selecting suitable PROMs to assess medical adherence.
Citation
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