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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Jan 22, 2020
Date Accepted: Feb 19, 2020

The final, peer-reviewed published version of this preprint can be found here:

The Multiple Sclerosis Health Resource Utilization Survey (MS-HRS): Development and Validation Study

Ness NH, Haase R, Kern R, Schriefer D, Ettle B, Cornelissen C, Akguen K, Ziemssen T

The Multiple Sclerosis Health Resource Utilization Survey (MS-HRS): Development and Validation Study

J Med Internet Res 2020;22(3):e17921

DOI: 10.2196/17921

PMID: 32181745

PMCID: 7109610

Multiple Sclerosis Health Resource Utilization Survey (MS-HRS): Development of an adaptive survey on the health economics’ perspective on Multiple Sclerosis

  • Nils-Henning Ness; 
  • Rocco Haase; 
  • Raimar Kern; 
  • Dirk Schriefer; 
  • Benjamin Ettle; 
  • Christian Cornelissen; 
  • Katja Akguen; 
  • Tjalf Ziemssen

ABSTRACT

Background:

Survey-based studies are frequently used to describe the economic impact of MS. However, there is no validated health-resource survey available, preventing comparison of study results and meaningful conclusions regarding the efficiency of long-term treatments.

Objective:

To develop and validate the MS health-resource survey for use on tablet and paper.

Methods:

We developed and validated the MS health-resource survey consisting of 24 cost items for paper user and tablet. Data for validation came from two large German observational studies. Survey practicability was assessed through response rate. Reliability was described using test-retest reliability as well as Guttman’s Lambda. Construct validity was assessed as convergent and discriminant validity via correlations with associated patient-reported outcomes and known-groups analyses.

Results:

In total, 2207 out of 2388 (response rate: 92.4%) patients completed the survey and were included to determine psychometric properties. Test-retest reliability was ICC=0.828 over a course of three months. Convergent validity analyses showed that total costs correlated positively with increased disability (r=0.411; p<0.001). For discriminant validity, correlations of total costs with the Treatment Satisfaction Questionnaire for Medication ranged from -0.006 (convenience) to -0.216 (effectiveness). Annual costs were 28,203±14,808€ (including DMTs).

Conclusions:

The MS-HRS is a multilingual, reliable, valid, electronically available and easy to administer questionnaire providing a holistic cross-sectional and longitudinal assessment of resource utilization in persons with MS.


 Citation

Please cite as:

Ness NH, Haase R, Kern R, Schriefer D, Ettle B, Cornelissen C, Akguen K, Ziemssen T

The Multiple Sclerosis Health Resource Utilization Survey (MS-HRS): Development and Validation Study

J Med Internet Res 2020;22(3):e17921

DOI: 10.2196/17921

PMID: 32181745

PMCID: 7109610

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