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Accepted for/Published in: JMIR Mental Health

Date Submitted: Oct 14, 2019
Date Accepted: Apr 9, 2020

The final, peer-reviewed published version of this preprint can be found here:

Causal Factors of Anxiety and Depression in College Students: Longitudinal Ecological Momentary Assessment and Causal Analysis Using Peter and Clark Momentary Conditional Independence

Huckins JF, DaSilva AW, Hedlund EL, Murphy EI, Rogers C, Wang W, Obuchi M, Holtzheimer PE, Wagner DD, Campbell AT

Causal Factors of Anxiety and Depression in College Students: Longitudinal Ecological Momentary Assessment and Causal Analysis Using Peter and Clark Momentary Conditional Independence

JMIR Ment Health 2020;7(6):e16684

DOI: 10.2196/16684

PMID: 32519971

PMCID: 7315365

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Towards Causal Factors of Anxiety and Depression in College Students: Longitudinal Ecological Momentary Assessments to Disentangle Causation and Correlation

  • Jeremy F Huckins; 
  • Alex W DaSilva; 
  • Elin L Hedlund; 
  • Eilis I Murphy; 
  • Courtney Rogers; 
  • Weichen Wang; 
  • Mikio Obuchi; 
  • Paul E Holtzheimer; 
  • Dylan D Wagner; 
  • Andrew T Campbell

ABSTRACT

Background:

Across college campuses the prevalences of depression and anxiety are both more than 18%, affecting 30% of the college population at some point between entry to college and graduation. Stress and self-esteem have both been hypothesized to contribute to depression and anxiety levels.

Objective:

Here we aim to determine the causal network between these factors.

Methods:

Ecological momentary assessments (EMAs) including depression, anxiety, stress and state self-esteem were obtained weekly from two cohorts of students for 40 weeks (one academic year). We used the Peter and Clark Momentary Conditional Independence (PCMCI) algorithm to identify the causal network structure between these mental health metrics.

Results:

Increased stress was a causal factor for anxiety while lower self-esteem was a causal factor for depression and, to a lesser extent, anxiety across both cohorts.

Conclusions:

The current work is an initial attempt to describe the contemporaneous and causal relationships among these four mental health metrics in college students. We replicated previous research identifying concurrent relationships between these variables and extended them by identifying causal links among these metrics. Our results support the Vulnerability Model of depression and anxiety. Understanding how causal factors impact the evolution of these mental states over time may provide key information for targeted treatment or, perhaps more importantly, interventions for individuals at risk for depression and anxiety.


 Citation

Please cite as:

Huckins JF, DaSilva AW, Hedlund EL, Murphy EI, Rogers C, Wang W, Obuchi M, Holtzheimer PE, Wagner DD, Campbell AT

Causal Factors of Anxiety and Depression in College Students: Longitudinal Ecological Momentary Assessment and Causal Analysis Using Peter and Clark Momentary Conditional Independence

JMIR Ment Health 2020;7(6):e16684

DOI: 10.2196/16684

PMID: 32519971

PMCID: 7315365

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