Currently submitted to: JMIR Formative Research
Date Submitted: Jun 12, 2019
Open Peer Review Period: Jun 12, 2019 - Jun 20, 2019
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Trends in scientific reports on cartilage bioprinting: A scoping review
Satisfactory therapeutic strategies for cartilaginous lesion repair do not yet exist, creating a challenge for surgeons and biomedical engineers, and leading them to investigate the role of bioprinting and tissue engineering as viable treatments through orthopedic surgery, plastic surgery, and otorhinolaryngology. Recent increases in related scientific literature suggest that bioprinted cartilage may develop into a viable solution.
The objectives of this review were a) synthesize the scientific advances published to date, b) identify unresolved technical problems regarding human application, and (c) identify more effective ways for the scientific community to transfer their findings to clinicians.
This scoping review considered articles published between 2011 and 2019 that were identified through searching PubMed, Science Direct, Web of Science, and Google Scholar. Arksey and O'Malley‚Äôs five-step framework was used to delimit and direct the initial search results, from which we established the following research questions: What do the authors say about current research on potential human applications? What improvements are needed in the technical aspects? On which issues do the authors agree? What proposals prioritize the authors‚Äô next steps? We used Cohen's kappa to validate the interrater reliability.
The 13 articles included in the review demonstrated the feasibility of cartilage bioprinting in live animal studies. Some investigators are already considering short-term human experimentation, although technical limitations still need to be resolved. Both the use and manufacturing process of stem cells need to be standardized, and a consensus is needed regarding the composition of hydrogels. Using on-site printing strategies and pre-designed implants may allow techniques to adapt to multiple situations. In addition, the predictive capacity of implant behavior may lead to optimal results.
Cartilage bioprinting for surgical applications is nearing initial use in humans. Current research suggests that soon surgeons will be able to replace damaged tissue with bioprinted material. Clinical Trial: Not applicable
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