Accepted for/Published in: JMIR Research Protocols
Date Submitted: Dec 16, 2018
Open Peer Review Period: Dec 17, 2018 - Dec 3, 2018
Date Accepted: Jan 18, 2019
(closed for review but you can still tweet)
Time to Treatment and Major Adverse Cardiac Events among Patients with ST-segment Elevation Myocardial Infarction (STEMI) Underwent Primary Percutaneous Coronary Intervention (PCI) according to Tehran Heart Center`s 24/7 Primary PCI Service Registry in Iran: Protocol for a Cross- sectional Study
ABSTRACT
Background:
Patients with ST- segment elevation myocardial infarction (STEMI) experience major adverse cardiac events (MACEs) following primary percutaneous coronary intervention (PCI). Although the relationship between time to treatment (e.g., door- to- balloon time, symptom onset to balloon time, and symptom onset to door time) and one- month all-cause mortality was assessed previously, its relationship with in- hospital MACEs, and effect of some clinical characteristics on this relationship were not considered. In other hand, previous studies were conducted in developed countries with different care quality which cannot be applied in Iran, as a developing country and they are not according to 24/7 primary PCI service registry.
Objective:
Thus, determining the relationship between time to treatment and in-hospital MACEs will be the objective of the protocol.
Methods:
In this cross- sectional study in the Tehran Heart Center (THC) affiliated to Tehran University of Medical Sciences (TUMS) (Tehran, Iran), data related to patients with STEMI underwent primary PCI between March 2015 and March 2019 that have been prospectively recorded in THC`s 24/7 primary PCI service registry will be analyzed. In-hospital MACEs are the study outcome. Data analysis will be conducted by SPSS, version 16, and by chi-squared test, independent samples t- test or Mann–Whitney U test, and univariate and multivariate binary logistic regression with a significance level of less than 0.05 and 95% confidence interval for odds ratio.
Results:
From March 2015 to September 2017, 1586 patients were included in the THC service registry, consecutively. Thus, we conduct a retrospective analysis of this registry between March 2015 to March 2019 and data will be analyzed and published at the end of 2019.
Conclusions:
According to our knowledge, this is the first observational study, according to 24/7 primary PCI service registry in Iran. The findings of this study may reveal current problem regarding time to treatment in STEMI management in THC. Thus, it may help to apply appropriate preventive strategies in order to reduce time to treatment delays and improve patients` outcomes following primary PCI in the setting of STEMI in THC and similar clinical centers.
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Copyright
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