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Rhedin S, Eklundh A, Ryd-Rinder M, Naucler P, Mårtensson A, Gantelius J, Zenk I, Andersson-Svahn H, Nybond S, Rasti R, Lindh M, Andersson M, Peltola V, Waris M, Alfvén T
Introducing a New Algorithm for Classification of Etiology in Studies on Pediatric Pneumonia: Protocol for the Trial of Respiratory Infections in Children for Enhanced Diagnostics Study
Trial of Respiratory infections in children for ENhanced Diagnostics (TREND) study protocol: introducing a new algorithm for classification of etiology in studies on pediatric pneumonia
Samuel Rhedin;
Annika Eklundh;
Malin Ryd-Rinder;
Pontus Naucler;
Andreas Mårtensson;
Jesper Gantelius;
Ingela Zenk;
Helene Andersson-Svahn;
Susanna Nybond;
Reza Rasti;
Magnus Lindh;
Maria Andersson;
Ville Peltola;
Matti Waris;
Tobias Alfvén
ABSTRACT
Background:
There is a need to better distinguish viral from antibiotic-requiring bacterial infections in children presenting with clinical community-acquired pneumonia (CAP) to assist healthcare workers’ decision-making and improve rational use of antibiotics.
Methods:
Children 1-59 months with clinical CAP as well as healthy hospital-based asymptomatic controls will be included at a pediatric emergency hospital in Stockholm, Sweden. Blood (analysed for myxovirus resistance protein A (MxA) and C-reactive protein (CRP)) and nasopharyngeal samples (analysed with real-time polymerase chain reaction as gold standard and antigen-based MariPOC® respi test as well as saved for later analyses by a new recombinase polymerase amplification based point-of-care test) will be collected. A newly developed algorithm for the classification of CAP etiology will be used as reference standard.
Discussion: The overall aim of the TREND study is to improve the differential diagnosis of bacterial and viral etiology in children below 5 years of age with clinical CAP, by evaluating MxA as a biomarker for viral CAP and by evaluating an existing (MariPOC® respi) and a potential future point-of-care test for respiratory pathogens. The findings from the TREND study can be an important step to improve the management of children with clinical CAP.
Trial registration: The study is registered at clinicaltrials.gov (ID:NCT03233516) July 28, 2017.
Citation
Please cite as:
Rhedin S, Eklundh A, Ryd-Rinder M, Naucler P, Mårtensson A, Gantelius J, Zenk I, Andersson-Svahn H, Nybond S, Rasti R, Lindh M, Andersson M, Peltola V, Waris M, Alfvén T
Introducing a New Algorithm for Classification of Etiology in Studies on Pediatric Pneumonia: Protocol for the Trial of Respiratory Infections in Children for Enhanced Diagnostics Study
