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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Jul 9, 2026
Date Accepted: Jul 22, 2026

The final, peer-reviewed published version of this preprint can be found here:

Digital Decisions: Enhancing Chronic Disease Self-Care Through Digital Health and AI-Enhanced Decision-Making

Griffin A, Zulman D

Digital Decisions: Enhancing Chronic Disease Self-Care Through Digital Health and AI-Enhanced Decision-Making

J Med Internet Res 2026;28:e106648

DOI: 10.2196/106648

PMID: 42594388

Digital Decisions: Enhancing Chronic Disease Self-Care Through Digital Health and AI-Enhanced Decision-Making

  • Ashley Griffin; 
  • Donna Zulman

ABSTRACT

Advances in digital health have dramatically changed how patients engage with their health. Rather than relying solely on periodic clinical visits, patients now have access to smartphones, patient portals, wearable devices, and mobile apps that provide support for day-to-day self-care decisions. This commentary discusses the findings of Longhini et al.'s systematic review and meta-analysis on the effectiveness of digital health interventions, which comprised multiple technologies and behavior change techniques across heterogenous patient populations living with chronic disease. The review found modest improvements in self-care monitoring but limited effects on self-care maintenance and management behaviors. Reflecting on these findings through the lens of dual-process theory, digital health technologies appear to be effective at supporting fast, intuitive processes, such as symptom monitoring, but are less effective at engaging slower, deliberative processes needed for complex decision-making and behavior change. Emerging AI capabilities offer opportunities to strengthen and bridge these cognitive processes by translating complex health information into actionable insights and facilitating patient-clinician communication. Realizing this potential requires careful attention to implementation, including integration into clinical workflows, patient and clinician education, digital literacy, and the use implementation science frameworks. Human-centered design, patient engagement, and safeguards addressing bias, privacy, and transparency are also foundational to ensure that the rapid pace of digital health technology will continue to enhance patient self-care and health outcomes.


 Citation

Please cite as:

Griffin A, Zulman D

Digital Decisions: Enhancing Chronic Disease Self-Care Through Digital Health and AI-Enhanced Decision-Making

J Med Internet Res 2026;28:e106648

DOI: 10.2196/106648

PMID: 42594388

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