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Currently submitted to: JMIR Formative Research

Date Submitted: Nov 26, 2025

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Digital Transformation of Personalized Medical Care: How to Overcome Health System Fragmentation Using the Example of Hereditary Breast and Ovarian Cancer Syndrome Care

  • Dorothee Speiser; 
  • Friederike Kendel; 
  • Paula Schneemann; 
  • Katharina Klein; 
  • Paula Thomas; 
  • Sandra Schmischke; 
  • Anna Karin Kubat; 
  • Jaap Dierking; 
  • Andre Sander; 
  • Stephanie Stegen; 
  • Stephen Schüürhuis; 
  • Christoph Kowalski; 
  • Sven Asmussen; 
  • Thomas Reinhold; 
  • Marlen Du Bois; 
  • Mandy Mangler; 
  • Andrea Sturm; 
  • Christine Olbrich; 
  • Jenny Katharina Wagner; 
  • Markus Feufel

ABSTRACT

Optimal patient care relies on close coordination between primary care practitioners and specialists across inpatient and outpatient settings. In many health care systems, primary and specialized care sectors often remain organizationally and technologically fragmented. As a result, patients and medical professionals across all specialties face overly complex care pathways that are difficult to navigate, frequently causing discontinuities of care. Although digital health technologies have the potential to reduce structural barriers and enhance coordination, many current applications are only partially integrated into existing digital infrastructure, poorly aligned with clinical workflows, or insufficiently adapted to varying levels of digital literacy. Rather than mitigating current fragmentations, these shortcomings risk creating new barriers and discontinuities in care pathways. Based on our work in the field of digital solutions in cross-sectoral care pathways, we outline the following key requirements for integrated digital solutions: (1) digital tools must support standardization while accommodating the flexibility of clinical practice; (2) they must be developed in modular components through close collaboration of all stakeholders involved in the care process to ensure low-threshold usability for patients and medical professionals; (3) digital tools must comply with prevailing IT-standards to ensure interoperability; and (4) digital tools must be scientifically evaluated in clinical and real-world settings. We illustrate these requirements using the example of a modular digital care platform designed to support all stakeholders involved in the inherently cross-sectoral care pathway for hereditary breast and ovarian cancer syndrome (HBOCS). Our experience shows that the success of digital health solutions in integrated care relies not only on technological performance, but also on interdisciplinary expertise, supportive infrastructure and policy, as well as openness to innovation in care delivery.


 Citation

Please cite as:

Speiser D, Kendel F, Schneemann P, Klein K, Thomas P, Schmischke S, Kubat AK, Dierking J, Sander A, Stegen S, Schüürhuis S, Kowalski C, Asmussen S, Reinhold T, Du Bois M, Mangler M, Sturm A, Olbrich C, Wagner JK, Feufel M

Digital Transformation of Personalized Medical Care: How to Overcome Health System Fragmentation Using the Example of Hereditary Breast and Ovarian Cancer Syndrome Care

JMIR Preprints. 26/11/2025:88369

DOI: 10.2196/preprints.88369

URL: https://preprints.jmir.org/preprint/88369

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