JMIR Publications

ABSTRACT

Bullous Pemphigoid (BP) is a chronic autoimmune blistering disease primarily affecting the elderly. It is characterized by the formation of tense blisters on erythematous or normal skin.1 The diagnosis of this condition in early stages can be particularly challenging, as it exhibits clinical manifestations that closely resemble those of a diverse array of other inflammatory disorders. The Koebner phenomenon (KP), first described by Heinrich Koebner in 1876, refers to the appearance of new skin lesions in previously unaffected areas of skin as a result of trauma. This phenomenon is alternatively known as the isomorphic response—a term derived from the Greek word for "equal shape"—owing to the observation that the newly formed lesions are clinically and histologically indistinguishable from the lesions characteristic of the patient's pre-existing dermatological condition.2 KP is seen in various dermatological conditions like psoriasis, vitiligo, and has recently been described in pemphigus vulgaris but seldom reported in BP.