JMIR Publications

ABSTRACT

In the rigid battle against cancer, an innovative strategy has emerged, one that seeks to harness the details of the cancer cell cycle to control its relentless growth. This review boards on a thorough exploration of the current landscape by studying the literature, aiming to shed light on manipulating cancer cells' division through the induction of a pause or rapid transition into the G0 phase. By meticulously evaluating existing studies, the authors navigate through various aspects, including the examination of malignant cells in early stages, clinical trials involving G0 phase-targeting chemotherapy, and the modulation of cell signaling mechanisms pivotal to the cell cycle. With a systematic approach, the investigation unfolds through in vitro experimentation and escalates into in vivo assessment, providing a comprehensive understanding of the subject matter. Crossing over the curve of the past five decades, this review dissects the trends in research, highlighting the evolution of insights into the complexities of the cancer cell cycle. However, among the endeavors to unravel its complexities, significant gaps and limitations remain. These gaps encompass the insufficient documentation of ontogeny, proto-oncogenes, and the complex process of carcinogenesis, evidence of the multifaceted challenges that persist in this field.