Previously submitted to: JMIR Public Health and Surveillance (no longer under consideration since Jun 15, 2024)
Date Submitted: Aug 28, 2023
Open Peer Review Period: Aug 27, 2023 - Sep 10, 2023
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Marijuana Use and Subjective Cognitive Decline in Middle-aged and Older Adults: Analysis of the Behavioral Risk Factor Surveillance System Survey
ABSTRACT
Background:
Marijuana impairs the brain development and function among adolescents, but little is known about whether marijuana use is associated with subjective cognitive decline (SCD) among adults.
Objective:
We investigated the cross-sectional association between marijuana use and SCD in a representative sample of US adults aged 45 years and older.
Methods:
The study population included 100,685 participants from five cycles of the Behavioral Risk Factor Surveillance System (BRFSS). Participants self-reported their marijuana use in the past month and whether they experienced SCD or SCD-related functional limitations in the past year. Participants were categorized into past-month marijuana non-users and past-month marijuana users. Among users, they were further classified as occasional (<10 days) and frequent users (≥ 10 days). The weighted, multivariable logistic regression models were fitted to examine the association between marijuana use and risk of SCD, adjusting for age, sex, educational level, chronic disease status, and other potential confounders (odds ratios [ORs] with 95% confidence intervals [95% CI]).
Results:
The sample included 94.2% past-month marijuana non-users, 5.83% users, and 3.45% frequent users. Compared with past-month marijuana non-use, past-month marijuana use was significantly associated with higher odds of SCD (OR = 1.71, 95% CI: 1.42, 2.06). The higher frequency was associated with higher odds of having SCD in a dose-response manner (p Trend < 0.001). Similar associations remained for the SCD-related functional limitations.
Conclusions:
Our findings provide initial evidence that marijuana use may adversely influence SCD among adults aged 45 years and older. Future prospective studies are warranted to confirm these findings. Clinical Trial: NA
Citation
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