Previously submitted to: Interactive Journal of Medical Research (no longer under consideration since Sep 30, 2022)
Date Submitted: Dec 28, 2021
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Interaction of High- and Low-Risk human papillomavirus genotypes is associated with a reduced risk of developing cervical cancer
ABSTRACT
Background:
Cervical cancer is among the most common type of cancers in women and is associated with human papillomavirus (HPV) infection.
Objective:
The link between cervical cancer and high-risk HPV infection has been well documented, although the effect of simultaneous infection with high- and low-risk HPV or low-risk HPV alone on the risk of developing cervical malignancy is remained to be unanswered in guideline
Methods:
We have investigated the association of high and low-risk HPVs (HR or LR) genotype with cervical carcinoma risk, as well as pathological and cytological information in cases recruited from a population-based cohort study of 790 patients.
Results:
The percentage of HR+LR and HR-HPV16/18 were 9.30% and 11.20% in class II, 7.15% and 7.10% in class IV and 7.15% and 5.80% in As-CUS smears. Interestingly concurrent infection with HR-HPV and LR-HPV types led to a notable decline in the risk of developing malignancy in comparison with the high-risk group (OR=0.3 (0.098-0.925), p-value=0.04). The percentage of individuals with cervical malignancy was 10.2% and 28.2% within the co-infected and the HR-HPV participants.
Conclusions:
Our finding demonstrated that simultaneous infection with high- and low-risk HPV reduces the risk of cervical malignancy.
Citation
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