Previously submitted to: JMIR Formative Research (no longer under consideration since Mar 30, 2022)
Date Submitted: Jun 3, 2021
Open Peer Review Period: Jun 3, 2021 - Jul 29, 2021
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Remote monitoring of vital and activity parameters in chronic transfusion dependent patients: a case-crossover pilot using wearable biosensors
ABSTRACT
Background:
Little is known if and to what extent outpatient RBC transfusions benefit chronic transfusion dependent patients. Costs, labour, and small but remaining side effects of RBC transfusions cause restrictive transfusions strategy to be the standard of care. However, the actual performance and quality of life of patients who require RBC’s on a regular basis are hardly accounted for.
Objective:
The aim of this study is to understand how new technologies and techniques like wearable biosensor devices and web-based testing can be used to measure physiological changes and functional activity in a cohort of transfusion-dependent patients.
Methods:
We monitored 5 patients who regularly receive transfusions during one transfusion cycle with the VitalPatch biosensor, the Withings Steel HR, and web-based cognitive and quality of life testing.
Results:
The deployed devices rendered qualitative and usable data. Heart rate and cognition showed to be significantly improved by RBC transfusions. Activity and quality of life measures did not show transfusion-induced changes.
Conclusions:
The accelerateIQ platform, Withings Steel HR, and the CANTAB platform are usable for extracting and analysing data. Red cell transfusions significantly and reversibly decrease heart rate and increase sustained attention in our cohort of five red cell transfusion-dependent patients.
Citation
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