Previously submitted to: JMIR Mental Health (no longer under consideration since Apr 28, 2021)
Date Submitted: Apr 27, 2021
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Can Salt Valproate Prevent Switch Associated With Antidepressants in Depressive Patients?Meta-analysis From Chinese Data
ABSTRACT
Background:
There are many ways to strengthen the effects of treatment for depressive patients,in which, add on mood stabilizer is one of these many ways. And at same time,it was very common that antidepressant induce switch to mania.Does the mood stabilizer can prevent the switch?This study is that assessment the difference between combination treatment of valproate and antidepressant and monotherapy antidepressant.
Objective:
to assess the preventing switch effect of valproate in depressive patients treated by antidepressant
Methods:
We searched Chinese Biomedical Database(CBM), China National Knowledge Infrastructure(CNKI) , WANFANG database,and Chinese Social Sciences Citation Index(CSSCI) in Chinese to find literature from 1 January 2005 to 1 January 2020 related to the study in model of “comparison of switch rate between combination treatment of valproate and antidepressant and monotherapy of antidepressant in depressive patients” ,among which results such as comments, letters, reviews and case reports were excluded. The rate of switch between groups was synthesized and discussed.
Results:
A total of 549 subjects were included in 7 studies,in which in 279 cases are in combination group and 270 cases are in group of monotherapy by antidepressant . Random effect model is used to account for the data by Revman 5.2. The results showed that the switch rate of valproate group was 0.11%(3/279),switch rate of antidepressant group was 11.11%( 30/270), which was very different in switch rate(OR=0.13 ,95% CI: 0.05–0.35) and also indicated that valproate reduced switch rate was 99%[ (11.11%-0.11%)/11.11%]. In sodium valproate group, switch rate was 0%，while switch rate in antidepressant was 5.7%( OR=0.18,95%CI=0.04-0.84),which was significantly different(Z=2.18,P=0.03). In magnesium valproate group, switch rate was 2.2%,while switch rate in antidepressant was16.92%( OR=0.11,95%CI=0.03-0.39),which was significantly different(Z=3.47,P=0.0005).
Conclusions:
The salt valproate can reduced switch rate related to antidepressant in depressive patients. In this study, salt valproate reduce 99% switch rate. Clinical Trial: NO
Citation
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