Currently submitted to: JMIR Preprints
Date Submitted: Jun 18, 2020
Open Peer Review Period: Jun 18, 2020 - Jun 3, 2021
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SARS-CoV-2 Biology Insights, Part I. Genome-wide structure and druggability: literature review
ABSTRACT
Background:
COVID-19 pandemic prompts the study of coronavirus biology and search of putative therapeutic strategies.
Objective:
To compare SARS-CoV-2 genome-wide structure and proteins with other coronaviruses, focusing on putative coronavirus-specific or SARS-CoV-2 specific therapeutic designs.
Methods:
The genome-wide structure of SARS-CoV-2 was compared to that of SARS and other coronaviruses in order to gain insights, doing a literature review through Google searches.
Results:
There are promising therapeutic alternatives. Host cell targets could be modulated to hamper viral replication, but targeting viral proteins directly would be a better therapeutic design, since fewer adverse side effects would be expected.
Conclusions:
Therapeutic strategies (Figure 1) could include the modulation of host targets (PARPs, kinases) , competition with G-quadruplexes or nucleoside analogs to hamper RDRP. The nicest anti-CoV options include inhibitors of the conserved essential viral proteases and drugs that interfere ribosome slippage at the -1 PRF site.
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