Previously submitted to: JMIR Medical Informatics (no longer under consideration since Jun 23, 2021)
Date Submitted: Apr 2, 2020
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
The Diagnosis of Early Cerebral Infarction Ischemic Penumbra in Compression Sensing Magnetic Resonance Diffusion Weighted Imaging and Perfusion Weighted Imaging
ABSTRACT
To investigate the diagnostic effect of compression-sensing-based magnetic resonance diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI) on the ischemic penumbra (IP) of early cerebral infarction in New Zealand rabbits, the New Zealand rabbit was selected as the research object, which was divided into the experiment group and the control group by constructing animal models. Rabbit models in both groups were subjected to magnetic resonance imaging (MRI) scans at different time nodes for the examination and observation of relevant indicators. In addition, the brain tissues of each group of rabbits were further stained and analyzed. The comparative analysis results of forehead cortex and basal ganglia in rabbit models indicated that with the increase of b value (the diffusion sensitivity coefficient of magnetic resonance), the signal of the frontal cortex was weakened, while the signal of the basal ganglia was enhanced; in addition, the overall image was gradually blurred, and the signal-to-noise ratio was increasing. The comparison results of signal intensity indicated that the larger the b value was, the more obvious the signal enhancement was. The analysis results of the changes in values of apparent diffusion coefficient (ADC) and the relative apparent diffusion coefficient (rADC) indicated that in the central lesion side of the basal node abnormal signals, the ADC and the rADC values first increased then decreased as the time increased. In addition, the ADC values in the mismatched area of DWI and PWI decreased to zero 6 h after cerebral ischemia, indicating that 6 h after ischemia, the sizes of DWI and PWI were the same, and the mismatched area disappeared. Further pathological examinations showed that with the increase of ischemia time, the neuronal deformation became more apparent. In addition, the mitochondrial membrane was lysed. Eventually, the mitochondria of vascular endothelial cells also showed edema, and the sputum disappeared. Compared with the traditional method, the dynamic magnetic resonance imaging method based on the compression sensing theory could better reconstruct the dynamic magnetic resonance images. Therefore, the experimental results suggested that the b value had obvious effects on the early detection and treatment of cerebral infarction. In addition, the existence of IP could be inferred based on ADC values. Despite the deficiencies in the experimental process, the results have provided experimental evidence for the clinical treatment of cerebral infarction diseases in the future.
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