Previously submitted to: Journal of Medical Internet Research (no longer under consideration since Aug 21, 2020)
Date Submitted: Mar 9, 2020
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Chinese Web-based Ocular Surface Disease Index (C-OSDI) Questionnaire in Dry Eye Patients: Reliability Study
ABSTRACT
Background:
Validated paper-based questionnaires such as the Ocular surface disease index (OSDI) provides a reliable assessment for patients’ ocular surface health. It is one of the most widely used survey instruments worldwide, following its first introduction in 1997.
Objective:
This study aimed to assess the reliability of the web-based version of OSDI in Chinese (C-OSDI) on clinically diagnosed dry eye (DE) patients
Methods:
A total of 265 Chinese patients (51% male, 129/254; mean age 27.90±9.06 years) with DE completed the paper-based and web-based questionnaires in a randomised crossover design. Ophthalmology examination and DE assessment were performed before the patients were invited to join the study. Patients were randomly assigned to group A (paper-based first and web-based second) or group B (web-based first and paper-based second). All patients included in the final data analysis had completed both versions of the C-OSDI questionnaire. Descriptive sociodemographic characteristics, test-retest reliability, and agreement rates for single items, subscale, and total score were analysed using intraclass correlation coefficients (ICC), Spearman rank correlation, and Wilcoxon test were used.
Results:
Reliability indexes were acceptable, with Pearson correlations greater than .8 and ICCs ranging from .827 to .982; total C-OSDI scores was not statistically different between the two versions. Patients’ survey revealed 72% (182/254) of the participants in this study preferred the web-based over the paper-based version.
Conclusions:
The web-based version of the C-OSDI questionnaire is reliable for patients with DED and demonstrated significant correlations with the paper-based version in all subscales and the total score. The web-based version of the C-OSDI questionnaire can be used to monitor individuals with DED as a majority of participants preferred the web-based version.
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