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Currently submitted to: Journal of Medical Internet Research

Date Submitted: Oct 23, 2026

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Artificial Intelligence Is Accelerating the Learning Health System – Can our Methods Keep Up?

  • Katy Trinkley; 
  • Alyssa Gatto; 
  • James Mitchell; 
  • David P. Kao

ABSTRACT

Artificial intelligence is accelerating healthcare intervention development and implementation, compressing learning cycles. Without corresponding advances in learning methods, health systems risk missing opportunities for improvement or deploying interventions without sufficient inquiry to ensure appropriateness and safety. We propose a new operating model for health system learning that tailors the timing and intensity of inquiry to intervention risks and opportunities for safe learning while embedding rigorous, continuous evaluation within care delivery. 


 Citation

Please cite as:

Trinkley K, Gatto A, Mitchell J, Kao DP

Artificial Intelligence Is Accelerating the Learning Health System – Can our Methods Keep Up?

JMIR Preprints. 23/10/2026:115228

DOI: 10.2196/preprints.115228

URL: https://preprints.jmir.org/preprint/115228

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